Valproic Acid (Depakene)

Anticonvulsionant treatment

Sample	Serum (Taken just before the next dose)
Schedule	Daily
Units	μmol/L
Range	Therapeutic range :  346 - 700  (Convertion: μmol/L x 0,1442 = μg/mL)
Remarks	Valproic acid is a first-choice drug for absence of seizures, generalized seizures and for the epileptic syndromes. (Synonyms: Depakene®, Depamide®, Divalproex®, Epilim®, Valproate®). Drug Therapeutic Range Toxic Level Half-Live Carbamazepine (Tegretol) 8 - 12 μg/mL > 12 μg/mL 15 - 40 hrs Digitoxin 18 - 35 ng/mL > 35 ng/mL 150 - 250 hrs Digoxin 0.8 - 2.0 ng/mL > 2.0 ng/mL 20 - 60 hrs Phenobarbital 20 - 40 μg/mL > 40 μg/mL 50 - 140 hrs Phenytoin (Epanutin) 10 - 20 μg/mL > 20 μg/mL 20 - 40 hrs Valproic Acid (Depakene) 346 - 700 μmol/L >700 μmol/L 8 - 15 hrs   Ôï ì